Venue: University of Pretoria Abstract: Living cells are dynamic, adaptive systems — rich in feedback, noise, and nonlinear behavior. Opto-cybergenetics is an emerging discipline that merges control theory, synthetic biology, and optogenetics to bring such systems under real-time feedback control. By coupling cells to computers through light-based signaling, we can now measure and modulate gene expression dynamically, enabling precise and […]

Abstract: Biological systems achieve remarkable robustness: cells maintain homeostasis and adapt precisely to environmental changes despite stochasticity, delays, and parametric uncertainty. How do they accomplish this, and how can we replicate such capabilities in synthetic systems? In this lecture, I will present a theoretical framework for robust perfect adaptation (RPA) in biomolecular networks, revealing deep […]

Venue: University of Cape Town Abstract: The ability to program living cells with designed feedback circuits is transforming biotechnology and medicine. Cybergenetics unites control theory and synthetic biology to endow cells with regulatory functions once limited to engineered systems. In this lecture, I will describe how theoretical insights into feedback and adaptation are being translated into the design and […]