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DTSTART:20250101T000000
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DTSTART;TZID=Africa/Johannesburg:20260203T180000
DTEND;TZID=Africa/Johannesburg:20260203T190000
DTSTAMP:20251113T124702Z
CREATED:20251104T142005Z
LAST-MODIFIED:20251113T124702Z
UID:1688-1770141600-1770145200@sacac.org.za
SUMMARY:Opto-Cybergenetics for Bioreactor Optimization: Feedback Control of Cellular Function with Light
DESCRIPTION:Venue: University of Pretoria \n \nAbstract: Living cells are dynamic\, adaptive systems — rich in feedback\, noise\, and nonlinear behavior. Opto-cybergenetics is an emerging discipline that merges control theory\, synthetic biology\, and optogenetics to bring such systems under real-time feedback control. By coupling cells to computers through light-based signaling\, we can now measure and modulate gene expression dynamically\, enabling precise and optimal control of biological processes. In this talk\, I will present recent advances in closed-loop optogenetic control for biotechnology. In one example\, feedback regulation of the unfolded protein response in yeast maintained gene expression at near-optimal levels\, resulting in increased protein yields. In another\, dynamic cybergenetic control was used to stabilize and reprogram the composition of bacterial co-cultures in real time. Finally\, I will outline how these ideas extend toward fully autonomous genetic control systems\, where engineered circuits within cells perform their own regulation. Together\, these developments illustrate how opto-cybergenetics is transforming biotechnology into a truly cyber-physical discipline — one where light\, computation\, and living matter are seamlessly integrated through feedback. \nREGISTER NOW\nCo-hosted by SACAC and NITheCS
URL:https://sacac.org.za/event/opto-cybergenetics-for-bioreactor-optimization-feedback-control-of-cellular-function-with-light/
LOCATION:University of Pretoria
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